ea0041ep859 | Pituitary - Basic | ECE2016
Ciato Denis
, Regazzo Daniela
, Occhi Gianluca
, Scaroni Carla
, Stalla Gunter
, Paez-Pereda Marcelo
Heat shock protein 90 (HSP90) plays a pivotal role in maturation and stabilization of proteins in conditions of stress. Many HSP90 client proteins are involved in oncogenic signaling and cancer progression, therefore HSP90 inhibitors have a potential as pharmaceutical agents. We reported a strong HSP90 overexpression in corticotroph adenomas and the treatment with C-terminal HSP90 inhibitors has potent anti-tumorigenic and anti-secretory effects in these tumors in vitro</e...